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Prog Neuropsychopharmacol Biol Psychiatry. 2013 Oct 1;46:214-23. doi: 10.1016/j.pnpbp.2012.10.017. Epub 2012 Nov 2.

Antioxidants as potential therapeutics for neuropsychiatric disorders.

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Department of Psychiatry and Health Behavior, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA.


Oxidative stress has been implicated in the pathophysiology of many neuropsychiatric disorders such as schizophrenia, bipolar disorder, major depression etc. Both genetic and non-genetic factors have been found to cause increased cellular levels of reactive oxygen species beyond the capacity of antioxidant defense mechanism in patients of psychiatric disorders. These factors trigger oxidative cellular damage to lipids, proteins and DNA, leading to abnormal neural growth and differentiation. Therefore, novel therapeutic strategies such as supplementation with antioxidants can be effective for long-term treatment management of neuropsychiatric disorders. The use of antioxidants and PUFAs as supplements in the treatment of neuropsychiatric disorders has provided some promising results. At the same time, one should be cautious with the use of antioxidants since excessive antioxidants could dangerously interfere with some of the protective functions of reactive oxygen species. The present article will give an overview of the potential strategies and outcomes of using antioxidants as therapeutics in psychiatric disorders.


Antioxidant; BDNF; BPRS; Brain-derived neurotrophic factor; Brief Psychiatric Rating Scale; CAT; Catalase; DHA; Docosahexaenoic; EEG; EPA; Eicosapentaenoic acid; Electroencephalography; GPx; GR; GSH; GST; Glutathione S transferase; Glutathione peroxidase; Glutathione reductase; N-acetyl- cysteine; NAC; NO; NO(−); NO+; Neuropsychiatric disorders; Nitrosonium cation (NO+); Nitrous oxide; Nitroxyl anion; ONOO(−); Oxidative stress; PANSS; PUFAs; Peroxynitrite; Polyunsaturated fatty acids; Positive and Negative Syndrome Scale; RNS; ROS; Reactive nitrogen species; Reactive oxygen species; Reduced glutathione; SOD; Superoxide dismutase; TAS; TBARS; Total antioxidant status; thiobarbituric acid reactive substances

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