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J Surg Res. 2013 Mar;180(1):51-5. doi: 10.1016/j.jss.2012.10.008. Epub 2012 Oct 29.

Detection of patients at high risk for non-occlusive mesenteric ischemia in hemodialysis.

Author information

1
Nephrology Department, Hospital Gregorio Marañón, Madrid, Spain. borjaqg@gmail.com

Abstract

BACKGROUND:

Nonocclusive mesenteric ischemia (NOMI) is an emerging condition in hemodialysis (HD) patients not widely studied.

MATERIALS AND METHODS:

A retrospective study was conducted between 2003 and 2011. NOMI cases were recorded, and demographic, clinical, biochemical, and HD parameters were collected. This group was compared with a control group (n = 93). Risk factors, prognosis, and survival were analyzed.

RESULTS:

There were 57 episodes of NOMI (incidence, 2.29 episodes per 100 patients/y). Cecum was the most frequently affected segment. Nineteen patients (33%) underwent surgery. Twenty-six patients (59%) did not survive the acute episode. Cecal damage was the only protective factor associated with mortality (relative risk [RR], 0.712; P = 0.044). The incidence of NOMI was related to erythropoietin resistance index, diabetes mellitus, and longer time on HD compared with control group (RR, 6.92, P = 0.009; RR, 9.98, P = 0.005; and RR, 1.017, P < 0.001, respectively). Mortality in survival NOMI patients was higher at 4-y follow-up compared with that in the control group (log-rank, 15.5; P < 0.0001).

CONCLUSIONS:

NOMI is associated with erythropoietin resistance index, diabetes mellitus, and longer time on HD. Hypotension must be avoided in these high-risk patients to prevent NOMI.

PMID:
23122519
DOI:
10.1016/j.jss.2012.10.008
[Indexed for MEDLINE]

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