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Trends Immunol. 2013 Feb;34(2):67-73. doi: 10.1016/j.it.2012.10.004. Epub 2012 Oct 31.

Type I interferon response and innate immune sensing of cancer.

Author information

1
Department of Pathology, University of Chicago, Chicago, IL, USA.

Abstract

Unexpectedly, many cancers appear to induce a spontaneous adaptive T cell response. The presence of a T cell infiltrate has been linked to favorable clinical outcome in multiple cancer types. However, the innate immune pathways that bridge to an adaptive immune response under sterile conditions are poorly understood. Recent data have indicated that tumors can induce type I interferon (IFN) production by host antigen-presenting cells (APCs), which is required for a spontaneous T cell response in vivo. The innate immune sensing pathways that trigger type I IFN production are being elucidated. Host type I IFNs are also required for optimal therapeutic efficacy with radiation. This recently uncovered role for host type I IFNs for antitumor immunity has important fundamental and clinical implications.

PMID:
23122052
PMCID:
PMC3565059
DOI:
10.1016/j.it.2012.10.004
[Indexed for MEDLINE]
Free PMC Article

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