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PLoS One. 2012;7(10):e48307. doi: 10.1371/journal.pone.0048307. Epub 2012 Oct 31.

Chronic medical conditions and risk of sepsis.

Author information

1
Department of Emergency Medicine, University of Alabama School of Medicine, Birmingham, Alabama, United States of America. hwang@uabmc.edu

Abstract

BACKGROUND:

We sought to determine the associations between baseline chronic medical conditions and future risk of sepsis.

METHODS:

Longitudinal cohort study using the 30,239 community-dwelling participants of the REGARDS cohort. We determined associations between baseline chronic medical conditions and incident sepsis episodes, defined as hospitalization for an infection with the presence of infection plus two or more systemic inflammatory response syndrome criteria.

RESULTS:

Over the mean observation time of 4.6 years (February 5, 2003 through October 14, 2011), there were 975 incident cases of sepsis. Incident sepsis episodes were associated with older age (p<0.001), white race (HR 1.39; 95% CI: 1.22-1.59), lower education (p<0.001) and income (p<0.001), tobacco use (p<0.001), and alcohol use (pā€Š=ā€Š0.02). Incident sepsis episodes were associated with baseline chronic lung disease (adjusted HR 2.43; 95% CI: 2.05-2.86), peripheral artery disease (2.16; 1.58-2.95), chronic kidney disease (1.99; 1.73-2.29), myocardial infarction 1.79 (1.49-2.15), diabetes 1.78 (1.53-2.07), stroke 1.67 (1.34-2.07), deep vein thrombosis 1.63 (1.29-2.06), coronary artery disease 1.61 (1.38-1.87), hypertension 1.49 (1.29-1.74), atrial fibrillation 1.48 (1.21-1.81) and dyslipidemia 1.16 (1.01-1.34). Sepsis risk increased with the number of chronic medical conditions (p<0.001).

CONCLUSIONS:

Individuals with chronic medical conditions are at increased risk of future sepsis events.

PMID:
23118977
PMCID:
PMC3485139
DOI:
10.1371/journal.pone.0048307
[Indexed for MEDLINE]
Free PMC Article

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