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Int J Rheumatol. 2012;2012:303506. doi: 10.1155/2012/303506. Epub 2012 Oct 16.

Is IgG4-Related Disease a Cause of Xerostomia? A Cohort Study of 60 Patients.

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1
Department of Internal Medicine, Regional Competence Group on Adults' Auto immune and Rare systemic diseases, G. Montpied Hospital, University Hospital of Clermont-Ferrand, 63003 Clermont-Ferrand Cedex 1, France.

Abstract

OBJECTIVE:

Immunoglobulin-G4-(IgG4-) related disease (IgG4 RD) is a fibrosing process characterized by a significant infiltration of IgG4-secreting plasma cells. IgG4 RD can affect almost all organs including salivary glands. Whether IgG4 RD plays a role in the development of sicca syndrome and particularly dry mouth syndrome remains to be investigated.

METHODS:

We conducted a monocentric cohort study for two years to search for IgG4 RD features in patients with dry mouth syndrome using immunostainings of labial salivary gland specimens with anti-IgG4 antibody.

RESULTS:

Among 60 patients presenting with dry mouth syndrome who underwent labial salivary gland biopsy, 18 showed positive immunostaining with the anti-IgG4 antibody including 4 patients with typical systemic IgG4 RD. Five also fulfilled criteria for Sjögren's syndrome.

CONCLUSION:

These findings suggest that clinical forms of IgG4 RD salivary involvement without salivary swelling may occur. This salivary involvement is probably overlooked in everyday practice and could represent a mild form of IgG4 RD.

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