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Transcription. 2012 Nov-Dec;3(6):305-9. doi: 10.4161/trns.21904. Epub 2012 Nov 1.

Akt1, EMSY, BRCA2 and type I IFN signaling: a novel arm of the IFN response.

Author information

1
Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA, USA.

Abstract

Interferon-stimulated transcription is thought to occur mainly through the action of the JAK/STAT pathway. However, recent findings revealed an additional PI3K/Akt-dependent pathway, which contributes to the induction of a set of interferon-stimulated genes (ISGs) through the regulation of the transcriptional repressor EMSY.

KEYWORDS:

Akt; BRCA2; EMSY; IRF9; ISRE; JAK/STAT pathway; interferon-stimulated gene (ISG)

PMID:
23117821
PMCID:
PMC3630186
DOI:
10.4161/trns.21904
[Indexed for MEDLINE]
Free PMC Article
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