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Cytokine. 2013 Jan;61(1):41-5. doi: 10.1016/j.cyto.2012.09.025. Epub 2012 Oct 30.

IL-15Rα deficiency leads to mitochondrial and myofiber differences in fast mouse muscles.

Author information

1
Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA. epistilli2@hsc.wvu.edu

Abstract

The purpose of this study was to determine mitochondrial changes in fast muscles from interleukin-15 receptor alpha knockout (IL-15RαKO) mice. We tested the hypothesis that fast muscles from IL-15RαKO mice would have a greater mitochondrial density and altered internal structure compared to muscles from control mice. In fast muscles from IL-15RαKO mice, mitochondrial density was 48% greater with a corresponding increase in mitochondrial DNA content. Although there were no differences in the relative size of isolated mitochondria, internal complexity was lower in mitochondria from IL-15RαKO mice. These data support an increase in mitochondrial biogenesis and provide direct evidence for a greater density and altered internal structure of mitochondria in EDL muscles deficient in IL-15Rα.

PMID:
23116661
PMCID:
PMC5317336
DOI:
10.1016/j.cyto.2012.09.025
[Indexed for MEDLINE]
Free PMC Article
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