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Biomarkers. 2013 Feb;18(1):88-94. doi: 10.3109/1354750X.2012.738250. Epub 2012 Nov 2.

Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer.

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1
Department of Medical Oncology, Marmara University Hospital, Istanbul, Turkey. taner.korkmaz@gmail.com

Abstract

CONTEXT:

TK1 found to be elevated biomarker in many solid cancers.

OBJECTIVES:

The study aimed to assess the prognostic significance of a serum TK1 in patients with metastatic NSCLC.

METHODS:

The study included 48 consecutive patients, newly diagnosed with metastatic NSCLC, and 10 healthy volunteers. Serum TK1 activity determined by ELISA method.

RESULTS:

Patients with a bTK1 level >156 Du L(-1) had significantly shorter survival. TK1 level showed a strong correlation with primary tumor SUV(max).

DISCUSSION AND CONCLUSION:

The magnitude of maximum fluorodeoxyglucose uptake in primary tumors and the serum TK1 level in patients with metastatic NSCLC were found to be independent prognostic predictors of overall survival.

PMID:
23116493
DOI:
10.3109/1354750X.2012.738250
[Indexed for MEDLINE]
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