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Rev Med Liege. 2012 Sep;67(9):461-7.

[Influence of body weight on the natural history of and the therapeutic approaches to type 1 diabetes].

[Article in French]

Author information

1
Service de Diabétologie, Nutrition et Maladies métaboliques et Unité de Pharmacologie clinique, Département de Médecine, CHU de Liège, Belgique.

Abstract

Obesity, whose prevalence is increasing in industrialized countries, is recognized as a major risk factor for the development of type 2 diabetes. In contrast, the role of excess adiposity in the natural history of type 1 diabetes (T1DM) and its impact on therapeutic approaches are by far less known and most probably largely underestimated. The following items will be most particularly considered: 1) the accelerator role of obesity in the development of T1DM in young predisposed individuals; 2) the difficult diagnosis in presence of hybrid or double diabetes combining insulin secretory defect and insulin resistance; 3) the problem of managing both body weight and glucose control, especially in young females and adolescents; 4) the possible deleterious effects of intensive insulin therapy on body weight and some markers of the metabolic syndrome; 5) the worse cardiovascular prognosis of T1DM patients when obesity is present; 6) the possible role of other medications as adjunct therapy to insulin in insulin resistant obese T1DM patients; and finally 7) the expected benefit of bariatric surgery in some well selected T1DM patients with severe obesity.

PMID:
23115847
[Indexed for MEDLINE]
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