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J Clin Microbiol. 2013 Jan;51(1):303-5. doi: 10.1128/JCM.02238-12. Epub 2012 Oct 31.

Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis.

Author information

1
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.

Abstract

The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.

PMID:
23115259
PMCID:
PMC3536230
DOI:
10.1128/JCM.02238-12
[Indexed for MEDLINE]
Free PMC Article

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