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Surg Today. 2013 Jan;43(1):26-32. doi: 10.1007/s00595-012-0345-z. Epub 2012 Nov 1.

Solid pseudopapillary neoplasms of the pancreas: an 18-year experience at a single Japanese Institution.

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1
Division of Hepato-Biliary-Pancreatic Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-cho, Aoba-ku, Sendai 980-8574, Japan.

Abstract

PURPOSE:

This study investigated the clinicopathological features and surgical management of solid pseudopapillary neoplasms at a single institution in Japan.

METHODS:

Seventeen patients (the largest series in Japan) those underwent surgery for pathologically confirmed solid pseudopapillary neoplasms were retrospectively reviewed.

RESULTS:

Sixteen patients were women and their mean age was 34.1 years. Most patients were asymptomatic (n = 11), and the average tumor diameter was 51.8 mm. The most common imaging characteristic was tumors of solid and cystic type (n = 10), which were most commonly located in the pancreatic body (n = 7). All patients underwent surgical exploration, i.e., distal pancreatectomies in 7 patients (laparoscopically performed in 2); middle pancreatectomies, 4; pancreaticoduodenectomies, 4; enucleation, 1; and liver resection, 1. No surgical mortalities occurred, and postsurgical complications occurred in 9 patients. Four patients had malignant tumors. One patient with liver metastases experienced recurrence, which was well controlled by paclitaxel. The remaining patients were disease free at a median follow-up of 51 months.

CONCLUSIONS:

Solid pseudopapillary neoplasms can be treated by complete tumor resection with limited resection or a minimally invasive approach when applicable. The combination of surgical resection and chemotherapy may therefore prolong survival, even in malignant cases.

PMID:
23114787
DOI:
10.1007/s00595-012-0345-z
[Indexed for MEDLINE]
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