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Lab Chip. 2012 Dec 21;12(24):5218-24. doi: 10.1039/c2lc40921f.

DropletMicroarray: facile formation of arrays of microdroplets and hydrogel micropads for cell screening applications.

Author information

1
Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Postfach 3640, 76021 Karlsruhe, Germany.

Abstract

We describe a one-step method for creating thousands of isolated pico- to microliter-sized droplets with defined geometry and volume. Arrays of droplets are instantly formed as liquid moves along a superhydrophilic-superhydrophobic patterned surface. Bioactive molecules, nonadherent cells, or microorganisms can be trapped in the fully isolated microdroplets for high-throughput screening, or in hydrogel micropads for screening in 3D microenvironments.

PMID:
23114283
DOI:
10.1039/c2lc40921f
[Indexed for MEDLINE]

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