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J Emerg Med. 2013 Apr;44(4):764-72. doi: 10.1016/j.jemermed.2012.07.055. Epub 2012 Oct 28.

Fresh frozen plasma for progressive and refractory angiotensin-converting enzyme inhibitor-induced angioedema.

Author information

1
Department of Emergency Medicine, New York Medical College, Metropolitan Hospital Center, New York, NY 10029, USA.

Abstract

BACKGROUND:

Angioedema secondary to angiotensin-converting enzyme inhibitors (ACEI) is a commonly encountered problem in the Emergency Department (ED). The treatment of ACEI-induced edema with conventional methods such as epinephrine, steroids, and antihistamines is usually not effective. There is limited experience using bradykinin receptor blockers and fresh frozen plasma (FFP) as a treatment modality for ACEI-induced angioedema.

OBJECTIVE:

To emphasize alternative treatment option for ACEI-induced angioedema in the ED.

CASE REPORTS:

We report a case series of progressive and refractory presumed ACEI-induced angioedema that all improved in temporal association with administration of FFP, with a brief review of the literature.

CONCLUSION:

There was a temporal association between the administration of FFP and improvement in angioedema in seven cases of presumed ACEI-induced angioedema that were refractory to antihistamines, corticosteroids, and epinephrine.

PMID:
23114109
DOI:
10.1016/j.jemermed.2012.07.055
[Indexed for MEDLINE]

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