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Bull Exp Biol Med. 2012 Sep;153(5):623-6.

Free and protein-bound angiotensin II(1-7)in the regulation of drinking behavior and hemodynamics in rats.

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Laboratory for Physiology of Motivations, PK Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia.


We compared physiological activity of synthetic analogues of endogenous protein-peptide compounds, complexes of angiotensin II(1-7)with functionally different proteins (transport protein, serum albumin; and neurospecific Ca(2+)-binding protein, S100b). Physiological activity of angiotensin II(1-7)was shown to depend on the type of a carrier protein. Our results suggest that complexes of angiotensins with BSA and S100b are strong factors for the integration of central and peripheral functions at the homeostatic and behavioral level.

[Indexed for MEDLINE]

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