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Bull Exp Biol Med. 2012 Sep;153(5):623-6.

Free and protein-bound angiotensin II(1-7)in the regulation of drinking behavior and hemodynamics in rats.

Author information

1
Laboratory for Physiology of Motivations, PK Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. lab_motiv@mail.ru

Abstract

We compared physiological activity of synthetic analogues of endogenous protein-peptide compounds, complexes of angiotensin II(1-7)with functionally different proteins (transport protein, serum albumin; and neurospecific Ca(2+)-binding protein, S100b). Physiological activity of angiotensin II(1-7)was shown to depend on the type of a carrier protein. Our results suggest that complexes of angiotensins with BSA and S100b are strong factors for the integration of central and peripheral functions at the homeostatic and behavioral level.

PMID:
23113241
[Indexed for MEDLINE]

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