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J Investig Med. 2013 Jan;61(1):11-4. doi: 10.2310/JIM.0b013e3182746f95.

Insulin signaling and insulin resistance.

Author information

1
Department of Medical Education, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA. elmus.beale@ttuhsc.edu

Abstract

Insulin resistance or its sequelae may be the common etiology of maladies associated with metabolic syndrome (eg, hypertension, type 2 diabetes, atherosclerosis, heart attack, stroke, and kidney failure). It is thus important to understand those factors that affect insulin sensitivity. This review stems from the surprising discovery that interference with angiotensin signaling improves insulin sensitivity, and it provides a general overview of insulin action and factors that control insulin sensitivity.

PMID:
23111650
PMCID:
PMC3640267
DOI:
10.2310/JIM.0b013e3182746f95
[Indexed for MEDLINE]
Free PMC Article

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