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Biol Chem. 2012 Nov;393(11):1279-90. doi: 10.1515/hsz-2012-0199.

The YidC/Oxa1/Alb3 protein family: common principles and distinct features.

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Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 7, NL-9747 AG Groningen, The Netherlands.


The members of the YidC/Oxa1/Alb3 protein family are evolutionary conserved in all three domains of life. They facilitate the insertion of membrane proteins into bacterial, mitochondrial, and thylakoid membranes and have been implicated in membrane protein folding and complex formation. The major classes of substrates are small hydrophobic subunits of large energy-transducing complexes involved in respiration and light capturing. All YidC-like proteins share a conserved membrane region, whereas the N- and C-terminal regions are diverse and fulfill accessory functions in protein targeting.

[Indexed for MEDLINE]

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