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Bioengineered. 2013 May-Jun;4(3):126-9. doi: 10.4161/bioe.22649. Epub 2012 Oct 30.

Cell fusion and hybrids in Archaea: prospects for genome shuffling and accelerated strain development for biotechnology.

Author information

1
Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

Abstract

The ability to exchange DNA between cells is a molecular process that exists in different species in the domain Archaea. Such horizontal gene transfer events were shown to take place between distant species of archaea and to result in the transfer of large genomic regions. Here we describe recent progress in this field, discuss the potential use of natural gene exchange processes to perform genome shuffling and argue its possible biotechnological applications.

KEYWORDS:

Archaea; Cell fusion; Haloferax mediterranei; Haloferax volcanii; Sulfolobus

PMID:
23111319
PMCID:
PMC3669151
DOI:
10.4161/bioe.22649
[Indexed for MEDLINE]
Free PMC Article

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