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Arch Biochem Biophys. 2013 Jun;534(1-2):3-10. doi: 10.1016/j.abb.2012.10.009. Epub 2012 Oct 27.

Pluripotent stem cells as a model to study oxygen metabolism in neurogenesis and neurodevelopmental disorders.

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1
Laboratório Nacional de Células-Tronco Embrionárias, Instituto de Ciências Biomédicas, UFRJ, Rio de Janeiro RJ 21941-913, Brazil.

Abstract

Reactive oxygen species (ROS) and oxygen (O2) have been implicated in neurogenesis and self-renewal of neural progenitor cells (NPCs). On the other hand, oxidative unbalance, either by an impairment of antioxidant defenses or by an intensified production of ROS, is increasingly related to risk factors of neurodevelopmental disorders, such as schizophrenia. In this scenario, human induced pluripotent stem cells (hiPSCs) emerged as an interesting platform for the study of cellular and molecular aspects of this mental disorder, by complementing other experimental models, with exclusive advantages such as the recapitulation of brain development. Herein we discuss the role of O2/ROS signaling for neuronal differentiation and how its unbalance could be related to neurodevelopmental disorders, such as schizophrenia. Identifying the role of O2/ROS in neurogenesis as well as tackling oxidative stress and its disturbances in schizophrenic patients' derived cells will provide an interesting opportunity for the study of neural stem cells differentiation and neurodevelopmental disorders.

PMID:
23111185
DOI:
10.1016/j.abb.2012.10.009
[Indexed for MEDLINE]
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