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Korean J Pathol. 2012 Aug;46(4):395-8. doi: 10.4132/KoreanJPathol.2012.46.4.395. Epub 2012 Aug 23.

Primary endometrial squamous cell carcinoma: a case report and review of relevant literature on korean women.

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Department of Obstetrics and Gynecology, St. Vincent's Hospital, The Catholic University of Korea School of Medicine, Suwon, Korea.


Primary endometrial squamous cell carcinoma (PESCC) is an extremely rare tumor with unclear pathogenesis. A 54-year-old postmenopausal woman presented with a 6-month history of vaginal bleeding. The patient was provisionally diagnosed with uterine submucosal leiomyoma. This was followed by total hysterectomy with a bilateral salpingo-oophorectomy under the laparoscopic guidance. Histopathologically, the tumor was PESCC which was accompanied by a lack of the tumor in the uterine cervix. The tumor showed positive immunoreactivity for p(16INK4a). But there was no evidence of human papillomavirus (HPV) on in situ hybridization and HPV DNA chip analysis. We also present a review of the relevant literature on Korean women.


Carcinoma, squamous cell; Endometrium; Genes, p16; Human papillomavirus; In situ hybridization

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