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Korean J Pathol. 2012 Aug;46(4):382-6. doi: 10.4132/KoreanJPathol.2012.46.4.382. Epub 2012 Aug 23.

Multifocal renal cell carcinoma of different histological subtypes in autosomal dominant polycystic kidney disease.

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Department of Pathology, Kyung Hee University School of Medicine, Seoul, Korea.


Renal cell carcinoma (RCC) in autosomal dominant polycystic kidney (ADPKD) is rare. To date, 54 cases of RCC in ADPKD have been reported. Among these, only 2 cases have different histologic types of RCC. Here we describe a 45-year-old man who received radical nephrectomy for multifocal RCC with synchronous papillary and clear cell histology in ADPKD and chronic renal failure under regular hemodialysis. The case reported herein is another example of the rare pathological finding of RCC arising in a patient with ADPKD.


Carcinoma, renal cell; Clear cell; Papillary; Polycystic kidney, autosomal dominant

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