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Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12602-5. doi: 10.1002/anie.201205308. Epub 2012 Oct 26.

Analysis of peptide secondary structures by photoactivatable amino acid analogues.

Author information

1
Pharmaceutical Chemistry and Bioanalytics, Martin-Luther-Universität Halle-Wittenberg, Institut für Pharmazie, Wolfgang-Langenbeck-Strasse 4, 06108 Halle, Germany. knut.koelbel@pharmazie.uni-halle.de

Abstract

Photochemical cross-linking was applied to trap intramolecular interactions in peptides. The incorporation of diazirine-labeled amino acid analogues in combination with high-resolution mass spectrometry made it possible to catch reverse-turn conformations within peptides, exactly map their self-interacting surfaces, and discriminate between stable and transient interactions.

PMID:
23109332
DOI:
10.1002/anie.201205308
[Indexed for MEDLINE]

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