Format

Send to

Choose Destination
Ann Neurol. 2012 Oct;72(4):559-63. doi: 10.1002/ana.23653.

Acid-sensing ion channel 1: a novel therapeutic target for migraine with aura.

Author information

1
Headache Group, Department of Neurology, University of California at San Francisco, San Francisco, CA 94115, USA.

Abstract

OBJECTIVE:

Migraine with aura is a severe debilitating neurological disorder with few relatively specific therapeutic options.

METHODS:

We used amiloride, a blocker of epithelial sodium channels, to evaluate its pharmacological potential and explored the biology of a potential mechanism of action in well-established experimental models.

RESULTS:

Amiloride was shown to block cortical spreading depression, the experimental correlate of aura, and inhibited trigeminal activation in in vivo migraine models, via an acid-sensing ion channel 1 mechanism. Remarkably, amiloride then demonstrated good clinical efficacy in a small open-labeled pilot study of patients, reducing aura and headache symptoms in 4 of 7 patients with otherwise intractable aura.

INTERPRETATION:

The observations here identify an entirely novel treatment strategy for migraine.

PMID:
23109150
DOI:
10.1002/ana.23653
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center