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Braz J Otorhinolaryngol. 2012 Oct;78(5):116-20.

Non syndromic cleft lip and palate: relationship between sex and clinical extension.

[Article in English, Portuguese]

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 State University of Montes Claros, Montes Claros, MG, Brazil.


Cleft lip and/or palate represent the most common congenital anomaly of the face.


To describe the correlation between non-syndromic cleft lip and/or palate and gender, and its severity in the Brazilian population.


Cross-sectional study, between 2009 and 2011, in a sample of 366 patients. The data was analyzed with descriptive statistics and multinomial logistic regression with a 95% interval to estimate the likelihood of the types of cleft lip and/or palate affecting the genders.


Among the 366 cases of non-syndromic cleft lip and/or palate, the more frequent clefts were cleft lip and palate, followed respectively by cleft lip and cleft palate. The cleft palates were more frequent in females, while the cleft lip and palate and cleft lips only predominated in males. The risk of cleft li in relation the cleft palate was 2.19 times in males when compared to females; while the risk of cleft lip and palate in relation to cleft palate alone was 2.78 times in males compared to females.


This study showed that there were differences in the distribution of the non-syndromic cleft lip and/or palate between males and females.

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