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Bioessays. 2012 Dec;34(12):1025-34. doi: 10.1002/bies.201200073. Epub 2012 Oct 26.

Introns in UTRs: why we should stop ignoring them.

Author information

1
Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA.

Abstract

Although introns in 5'- and 3'-untranslated regions (UTRs) are found in many protein coding genes, rarely are they considered distinctive entities with specific functions. Indeed, mammalian transcripts with 3'-UTR introns are often assumed nonfunctional because they are subject to elimination by nonsense-mediated decay (NMD). Nonetheless, recent findings indicate that 5'- and 3'-UTR intron status is of significant functional consequence for the regulation of mammalian genes. Therefore these features should be ignored no longer.

PMID:
23108796
DOI:
10.1002/bies.201200073
[Indexed for MEDLINE]

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