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Autophagy. 2013 Feb 1;9(2):252-4. doi: 10.4161/auto.22585. Epub 2012 Oct 29.

Microautophagy in the visceral endoderm is essential for mouse early development.

Author information

1
Division of Biological Science, Institute for Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan. yohwada@sanken.osaka-u.ac.jp

Abstract

During early embryogenesis, before the conceptus forms the placenta, maternal nutrients as well as signaling molecules must reach the embryo proper through a tightly sealed epithelial tissue, the visceral endoderm (VE). The VE serves as a signaling center for embryogenesis, where exocytic and endocytic processes integrate signal production, perception and termination. However, the endocytic process in this important tissue has not been well characterized. We show that endocytic delivery to the lysosomes occurs via RAB7-dependent microautophagy. This process is essential for early mammalian development.

KEYWORDS:

RAB7; apical vacuole; autophagy; early mouse development; microautophagy

PMID:
23108279
PMCID:
PMC3552893
DOI:
10.4161/auto.22585
[Indexed for MEDLINE]
Free PMC Article
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