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Obes Facts. 2012;5(5):641-7. doi: 10.1159/000343507. Epub 2012 Oct 2.

Insulin resistance predicts the effectiveness of different glycemic index diets on weight loss in non-obese women.

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Department of Clinical and Experimental Medicine, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil.



The present study aimed to evaluate whether baseline insulin resistance (IR) modify weight change associated to glycemic index (GI) of the diet.


This is a secondary analysis of a randomized GI intervention according to baseline HOMA-IR. Middle-aged (25-45 years), non-obese (BMI 23-29.9 kg/m²) women were randomized to low or high GI diets matched on total energy, macronutrient composition, and fiber content. Both groups received dietary counseling based on a small energy restriction (100-300 kcal/day). Women were classified in two groups according to their baseline HOMA-IR: IR (n = 64) and non-IR (n = 121).


At baseline, IR and non-IR groups had similar BMI (26.7 vs. 26.3 kg/m²; p = 0.21), but the IR group presented with higher waist circumference (82.7 vs. 80.8 cm; p = 0.02) and showed greater weight loss after 12 months of follow-up (-1.6 vs. -1.1 kg; p = 0.01), mainly among those in a high-GI diet (-2.1 vs. -1.0 kg; p = 0.005) compared to the non-IR group (-1.4 vs. -0.8 kg; p = 0.04).


The high-GI group showed statistically significant higher reduction in body weight, mainly among those women with baseline IR . Low-GI diet did not facilitate weight loss neither in IR women nor in non-IR women.

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