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Obes Facts. 2012;5(5):641-7. doi: 10.1159/000343507. Epub 2012 Oct 2.

Insulin resistance predicts the effectiveness of different glycemic index diets on weight loss in non-obese women.

Author information

1
Department of Clinical and Experimental Medicine, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil. mffmediano@gmail.com

Abstract

OBJECTIVE:

The present study aimed to evaluate whether baseline insulin resistance (IR) modify weight change associated to glycemic index (GI) of the diet.

METHOD:

This is a secondary analysis of a randomized GI intervention according to baseline HOMA-IR. Middle-aged (25-45 years), non-obese (BMI 23-29.9 kg/m²) women were randomized to low or high GI diets matched on total energy, macronutrient composition, and fiber content. Both groups received dietary counseling based on a small energy restriction (100-300 kcal/day). Women were classified in two groups according to their baseline HOMA-IR: IR (n = 64) and non-IR (n = 121).

RESULTS:

At baseline, IR and non-IR groups had similar BMI (26.7 vs. 26.3 kg/m²; p = 0.21), but the IR group presented with higher waist circumference (82.7 vs. 80.8 cm; p = 0.02) and showed greater weight loss after 12 months of follow-up (-1.6 vs. -1.1 kg; p = 0.01), mainly among those in a high-GI diet (-2.1 vs. -1.0 kg; p = 0.005) compared to the non-IR group (-1.4 vs. -0.8 kg; p = 0.04).

CONCLUSIONS:

The high-GI group showed statistically significant higher reduction in body weight, mainly among those women with baseline IR . Low-GI diet did not facilitate weight loss neither in IR women nor in non-IR women.

PMID:
23108147
DOI:
10.1159/000343507
[Indexed for MEDLINE]
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