Format

Send to

Choose Destination
Gynecol Obstet Invest. 2013;75(1):21-7. doi: 10.1159/000341709. Epub 2012 Oct 25.

Tissue composition of the vaginal wall in women with pelvic organ prolapse.

Author information

1
Department of Gynecology and Obstetrics, Deventer Hospital, Deventer, The Netherlands.

Abstract

BACKGROUND/AIMS:

To determine the composition of the vaginal wall and to explore the connective tissue layer, muscularis and basement membrane in relation to the pathogenesis of pelvic organ prolapse (POP).

METHODS:

We performed a histopathological study with respect to the composition of the vaginal wall of 33 patients and 9 controls. Tissue samples from the vaginal wall were analysed for collagens II and IV, desmin, elastin, fibronectin, smooth muscle actin (SMA) and transforming growth factor (TGF)-β1 using (immuno)histochemistry. Morphometric analyses were also performed.

RESULTS:

Morphometric characteristics and expression of SMA, TGF-β1, elastin and collagen II were significantly altered in women with POP.

CONCLUSION:

Our results suggest that there could be an altered tissue composition of the vaginal wall in women with POP. SMA expression could play a role in the pathogenesis of POP. The alterations in elastin and TGF-β1 expression are likely a result of POP.

PMID:
23108059
DOI:
10.1159/000341709
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland
Loading ...
Support Center