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J Obstet Gynaecol Res. 2013 Mar;39(3):680-4. doi: 10.1111/j.1447-0756.2012.02016.x. Epub 2012 Oct 29.

Endometrial scratching to improve pregnancy rate in couples with unexplained subfertility: a randomized controlled trial.

Author information

1
Department of Obstetrics and Gynecology, Mansoura University, Mansoura, Egypt. ahmedfathgi@yahoo.com

Abstract

AIM:

The aim of this study was to examine the effect of endometrial scratching in women with unexplained infertility.

MATERIAL AND METHODS:

A randomized controlled trial was conducted in Mansoura University Teaching Hospital and a private practice setting. A total of 105 couples with unexplained infertility were randomly allocated into two groups: group A comprised 54 women who underwent endometrial scratching in the luteal phase of a spontaneous menstrual cycle; and group B included 51 women who underwent a placebo procedure. The main outcome measured was cumulative clinical pregnancy rate after 6 months and miscarriage rate.

RESULTS:

Clinical pregnancy rate was significantly higher in the women experiencing endometrial biopsy than in the control group (25.9% and 9.8%, respectively, P = 0.04). There was no significant difference in miscarriage rate between pregnant women in the endometrial injury group and pregnant women in the control group (12.5% and 16.5%, respectively, P = 0.79).

CONCLUSIONS:

Endometrial scratching may improve clinical pregnancy rates in couples with unexplained infertility. Adequately powered studies are mandated to confirm or refute the findings.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01412606.

[Indexed for MEDLINE]

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