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J Clin Invest. 2012 Sep;122(9):3044-5.

Complement, oxidants, and endothelial injury: how a bedside observation opened a door to vascular biology.

Author information

1
Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA. verce001@umn.edu

Abstract

A single encounter with a dialysis patient led to the study of complement and neutrophil aggregation, which in turn spawned our work and the remarkable development of the field of vascular biology. As our understanding of these cellular interactions and the signaling pathways involved in these processes has expanded, so has our appreciation for the broad impact of this work on an array of human diseases.

PMID:
23106086
PMCID:
PMC3428102
[Indexed for MEDLINE]
Free PMC Article
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