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Indian J Clin Biochem. 2010 Jan;25(1):77-81. doi: 10.1007/s12291-010-0016-z. Epub 2010 Feb 10.

Clinical correlation of alteration of endogenous antioxidant-uric acid level in major depressive disorder.

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Department of Pharmacology, Government Medical College Nagpur, Maharashtra, 440003 India ; Plot No: 66, Saraswati Society, Deendayal Nagar, Nagpur, Maharashtra India 440022.


Derangement of antioxidant levels in major depressive disorder had been correlated with oxidative damage. The effect of Selective Serotonin Re-Uptake Inhibitors on endogenous antioxidant uric acid levels in major depressive disorder has never been examined. This was a prospective; open labeled, parallel, 12 weeks study, in which serum uric acid levels and Hamilton Rating Scale for Depression score were estimated in age and sex matched thirty-six healthy and forty major depressive disorder subjects before and after fluoxetine and citalopram treatment. Significant decrease in serum uric acid (P<0.0001) was observed in newly diagnosed major depressive disorder subjects when compared to healthy subjects. The trend was reversed after 6 weeks more significantly after 12 weeks of treatment with improvement in Hamilton Rating Scale for Depression score. Also, Significant and negative correlation was found between Hamilton Rating Scale for Depression score and serum uric acid level (r= -0.864, P<0.001) after 12 weeks of treatment. Treatment with fluoxetine or citalopram reverses endogenous antioxidants like uric acid and improves Hamilton Rating Scale for Depression score in major depressive disorder.


Citalopram; Fluoxetine; Hamilton Rating Scale for Depression score; Major depression; Selective Serotonin Re-Uptake Inhibitors; Uric acid

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