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Indian J Clin Biochem. 2009 Jan;24(1):65-9. doi: 10.1007/s12291-009-0011-4. Epub 2009 May 8.

Hypoglycemic, lipid lowering and antioxidant activities in root extract of Anthocephalus indicus in alloxan induced diabetic rats.

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1
Department of Biochemistry, C S M Medical University, Lucknow, India.

Abstract

The present study was carried out to evaluate the hypoglycemic, lipid lowering and antioxidant activities in root extract of Anthocephalus indicus (A indicus) in alloxan inducd diabetic rats. Oral administration of ethanol extract of root (500mg/ kg body weight) for 21 days resulted in significant decrease in the levels of blood glucose, triglycerides, total cholesterol, phospholipid and free fatty acids. Furthermore, the root extract (100-400μg) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The result of the present study demonstrated hypoglycemic, lipid lowering and antioxidant activities in root extract of A indicus, which could help in prevention of diabetic dyslipidemia and related diseases.

KEYWORDS:

Anthocephalus indicus; Hypoglycemic agent; Lipid lowering agent; Oxygen free radical scavengers; Plant antioxidant

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