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Indian J Clin Biochem. 2007 Mar;22(1):131-4. doi: 10.1007/BF02912896.

Age related changes in lipid peroxidation and antioxidants in elderly people.

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Department of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Bejai, 575004 Mangalore, India.


Advanced age is associated with an accumulation of free radical damage, which leads to physiological and clinical modifications. Age related changes resulting from free radical reactions include increasing levels of lipid peroxides, alterations in enzyme activities and greater osmotic fragility. The present study was conducted to estimate the level of lipid peroxidation product-Malondialdehyde and antioxidants Catalase and Glutathione in elderly people. An increase in lipid peroxidation and decrease in antioxidants was observed in normal elderly people. Highly significant increase in MDA and decrease in antioxidants was observed in elderly people when complicated with diabetes and hypertension. Supplementation of antioxidants may prevent further oxidative injury in elderly people.


Antioxidants; Elderly people; Lipid peroxidation

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