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Indian J Clin Biochem. 2007 Mar;22(1):4-9. doi: 10.1007/BF02912873.

Brain type natriuretic peptide (BNP)-A marker of new millennium in diagnosis of congestive heart failure.

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Department of Clinical Biochemistry and Cardiology, Escorts Heart Insitute & Research Centre, 110025 New Delhi.


The burden of disease in patients with congestive heart failure is high. The future of BNP looks promising as it may be a better diagnostic tool for the diagnosis of CHF in developing countries in new millennium. Natriuretic peptide hormones, a family of vasoactive peptides with many favourable physiological properties, have emerged as important contenders for development of diagnostic tools and therapeutic agents in cardiovascular disease. Measurement of B-type natriuretic peptide has become as an easy-to-perform bedside test. The clinical and diagnostic significance of the measurement of plasma Nt-proBNP in the diseases of the cardiovascular system with particular emphasis on the assessment of patients with heart failure and their effects on predicting survival rate. The plasma levels of Nt-proBrain Natriuretic peptide responds more vigorously after myocardial infarction than those of other natriuretic peptides. This article is an attempt to give a short overview on the utility of BNP-blood levels for the diagnosis and treatment of heart failure.


Amino terminal pro brain natriuretic peptide; B-type Natriuretic peptide; Congestive heart failure; Left ventricular ejection fraction; Myocardial Infarction

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