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Indian J Clin Biochem. 2001 Jan;16(1):9-14. doi: 10.1007/BF02867562.

Antioxidants: Basis concepts in relation to the eye.

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Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, 29 New Delhi.


Antioxidants are a small group of substances that protect living cells from the destructive consequences of powerful oxidizing intermediates that can be formed from oxygen. Situations in which pro-oxidant mechanisms within the body are more active than the antioxidant mechanisms (oxidative stress) predispose and contribute to the pathogenesis of several ailments in various organs of the body. In the eye, pro-oxidant factors have been blamed for the causation of diseases such as age related macular degeneration and senile cataract. The role of pro-oxidants in the genesis of certain diseases is well established however, the effectivity of antioxidants provided to the body by dietary supplementation is inconclusive. In this article we provide a review on the basic concepts of antioxidant-pro-oxidant interaction in relation to its effects on the eye.


Antioxidants; Oxidative stress; Pro-oxidants

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