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Neuroimage. 2013 Feb 1;66:333-42. doi: 10.1016/j.neuroimage.2012.10.030. Epub 2012 Oct 24.

Statistical localization of human olfactory cortex.

Author information

1
Monell Chemical Senses Center, Philadelphia, PA, USA.
2
Clinic for Diagnostic and Interventional Neuroradiology, RWTH Aachen University, Aachen, Germany.
3
Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
4
Monell Chemical Senses Center, Philadelphia, PA, USA; Department of Psychology, University of Pennsylvania, PA, USA; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address: jlundstrom@monell.org.

Abstract

Functional neuroimaging methods have been used extensively during the last decades to explore the neural substrates of olfactory processing. While a general consensus on the functional anatomy of olfactory cortex is beginning to emerge, the mechanisms behind the functions of individual processing nodes still remain debated. Further, it remains unclear to which extent divergent findings result from differences in methodological approaches. Using Activation Likelihood Estimation (ALE), the aim of the present study was to statistically combine all published data on functional neuroimaging of olfaction to provide a probability map reflecting the state of the field to date. Additionally, we grouped studies according to various methodological approaches to investigate whether these systematically affected the reported findings. A total of 45 studies (69 contrasts, 594 foci) met our inclusion criteria. Significant ALE peaks for odor against baseline were observed in areas commonly labeled as primary and secondary olfactory cortex, such as the piriform and orbitofrontal cortex, amygdala, anterior insula, and ventral putamen. In addition, differences were observed in the extent to which different methods were able to induce activation in these different nodes of the olfactory network.

KEYWORDS:

Activation likelihood estimation; Brain imaging; Olfaction; Piriform cortex

[Indexed for MEDLINE]

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