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Clin Immunol. 2012 Dec;145(3):177-88. doi: 10.1016/j.clim.2012.10.001. Epub 2012 Oct 8.

The impact of pregnancy on the HIV-1-specific T cell function in infected pregnant women.

Author information

1
Department of Microbiology and Parasitology, Federal University of State of Rio de Janeiro, Rio de Janeiro, Brazil.

Abstract

Evidences indicate that pregnancy can alter the Ag-specific T-cell responses. This work aims to evaluate the impact of pregnancy on the in vitro HIV-1-specific immune response. As compared with non-pregnant patients, lower T-cell proliferation and higher IL-10 production were observed in T-cell cultures from pregnant patients following addition of either mitogens or HIV-1 antigens. In our system, the main T lymphocyte subset involved in producing IL-10 was CD4(+)FoxP3(-). Depletion of CD4(+) cells elevated TNF-α and IFN-γ production. Interestingly, the in vitro HIV-1 replication was lower in cell cultures from pregnant patients, and it was inversely related to IL-10 production. In these cultures, the neutralization of IL-10 by anti-IL-10 mAb elevated TNF-α release and HIV-1 replication. In conclusion, our results reveal that pregnancy-related events should favor the expansion of HIV-1-specific IL-10-secreting CD4(+) T-cells in HIV-1-infected women, which should, in the scenario of pregnancy, help to reduce the risk of vertical HIV-1 transmission.

PMID:
23103487
DOI:
10.1016/j.clim.2012.10.001
[Indexed for MEDLINE]

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