Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Immunol. 2013 Mar;34(3):137-43. doi: 10.1016/j.it.2012.10.001. Epub 2012 Oct 25.

Indoleamine 2,3 dioxygenase and metabolic control of immune responses.

Author information

1
Department of Pediatrics, Cancer Immunology, Inflammation and Tolerance Program, Cancer Center, Georgia Health Sciences University, Augusta GA 30912, USA.

Abstract

Sustained access to nutrients is a fundamental biological need, especially for proliferating cells, and controlling nutrient supply is an ancient strategy to regulate cellular responses to stimuli. By catabolizing the essential amino acid TRP, cells expressing the enzyme indoleamine 2,3 dioxygenase (IDO) can mediate potent local effects on innate and adaptive immune responses to inflammatory insults. Here, we discuss recent progress in elucidating how IDO activity promotes local metabolic changes that impact cellular and systemic responses to inflammatory and immunological signals. These recent developments identify potential new targets for therapy in a range of clinical settings, including cancer, chronic infections, autoimmune and allergic syndromes, and transplantation.

PMID:
23103127
PMCID:
PMC3594632
DOI:
10.1016/j.it.2012.10.001
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center