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Curr Opin Virol. 2012 Dec;2(6):764-72. doi: 10.1016/j.coviro.2012.09.012. Epub 2012 Oct 25.

The poxvirus C7L host range factor superfamily.

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Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, United States.


Host range factors, expressed by the poxvirus family, determine the host tropism of species, tissue, and cell specificity. C7L family members exist in the genomes of most sequenced mammalian poxviruses, suggesting an evolutionarily conserved effort adapting to the hosts. In general, C7L orthologs influence the host tropism in mammalian cell culture, and for some poxviruses it is essential for the complete viral life cycle in vitro and in vivo. The C7L family members lack obvious sequence homology with any other known viral or cellular proteins. Here we review recent findings from an evolutionary perspective and summarize recent progress that broadens our view on the role of C7L family members in mediating poxvirus host range and antagonizing the host defense system.

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