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Clin Imaging. 2013 May-Jun;37(3):440-5. doi: 10.1016/j.clinimag.2012.09.006. Epub 2012 Oct 25.

Acute irradiation injury of canine brain with pathology control is detected by diffusion-weighted imaging of MRI.

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Department of Radiation Oncology, JiNan Military General Hospital, District TianQiao, 250031, JiNan, Shandong, China.


To investigate the pathological changes of canine brain after irradiation and evaluate the effect of diffusion-weighted imaging (DWI), 25 healthy dogs were treated with 70 Gy (60)Coγ-ray irradiation on right temporal brain. Respectively, the apparent diffusion coefficient (ADC) values of canine alba and ectocinerea were measured by MRI T1 weighted imaging (T1WI), T2 weighted imaging (T2WI), and DWI. Compared with the control group, at every time point after irradiation, the ADC values of canine brain tissue were decreased significantly (P<.05). DWI is a very sensitive imaging technology that detects the changes of water molecule diffusion and microscopic pathological changes after canine brain irradiation.

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