Format

Send to

Choose Destination
Curr Opin Biotechnol. 2013 Feb;24(1):39-47. doi: 10.1016/j.copbio.2012.10.003. Epub 2012 Oct 25.

Metabolomics platforms for genome wide association studies--linking the genome to the metabolome.

Author information

1
Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany. adamski@helmholtz-muenchen.de

Abstract

Genome-wide association studies (GWAS) reveal links between genetic variance and predisposition to disease. With the advent of modern 'omics-technologies', GWAS can now identify the genetic factors that influence intermediate traits on pathways to disease, such as blood concentrations of carbohydrates, lipids, amino acids, and secondary metabolites, hormones and signal molecules. At the example of recent GWAS with metabolic traits (mGWAS) we review the high-throughput screening approaches that are available to further advance the field.

PMID:
23102864
DOI:
10.1016/j.copbio.2012.10.003
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center