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Cell. 2012 Oct 26;151(3):476-82. doi: 10.1016/j.cell.2012.10.012.

Revisiting global gene expression analysis.

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1
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

Abstract

Gene expression analysis is a widely used and powerful method for investigating the transcriptional behavior of biological systems, for classifying cell states in disease, and for many other purposes. Recent studies indicate that common assumptions currently embedded in experimental and analytical practices can lead to misinterpretation of global gene expression data. We discuss these assumptions and describe solutions that should minimize erroneous interpretation of gene expression data from multiple analysis platforms.

PMID:
23101621
PMCID:
PMC3505597
DOI:
10.1016/j.cell.2012.10.012
[Indexed for MEDLINE]
Free PMC Article
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