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Indian J Clin Biochem. 1997 Dec;12(Suppl 1):17-21. doi: 10.1007/BF02873047.

Detection of filarial antibody using an fiber optics immunosensor (FOI).

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1
Centre for Biomedical Engineering, Indian Institute of Technology, 110 016 New Delhi, India.

Abstract

Optical waveguides based immunoassay has been reported in the literature for the detection of pathogens likeC. botulinum and F1 antigen ofY. pestis (3) and also for the antibodies to pathogens like the Rubella virus (4) in the serum or the whole blood. In this line we have demonstrated the FOI for the detection ofS. digitata antibody. Experiments are in progress in our laboratory to standardise the sensor for detection of Bancroftian filariasis caused byW. bancrofti. Few modifications are also in the process so as to improve the signal amplification at evanescent region as well as to reduce the two step method into single step method. The FOI has an advantage over other conventional methods because no extensive washing steps are required and the whole procedure takes just 15 minutes to get the result. The FOI designed for this experiment can be made portable for use in the field level for epidemiological studies.

KEYWORDS:

Detection; Fiber Optic Immunosensor; Filariasis

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