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Cortex. 2014 Jul;56:111-20. doi: 10.1016/j.cortex.2012.09.010. Epub 2012 Sep 29.

Structural connectivity in a single case of progressive prosopagnosia: the role of the right inferior longitudinal fasciculus.

Author information

1
Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy.
2
IRCCS Fondazione SDN, Istituto di Ricerca Diagnostica e Nucleare, Naples, Italy.
3
Department of Neurological Sciences, School of Biotechnology, Federico II University of Naples, Italy.
4
Biostructure and Bioimaging Institute, CNR, Naples, Italy.
5
IRCCS Fondazione SDN, Istituto di Ricerca Diagnostica e Nucleare, Naples, Italy; Biostructure and Bioimaging Institute, CNR, Naples, Italy.
6
Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy. Electronic address: luigi.trojano@unina2.it.

Abstract

Progressive prosopagnosia (PP) is a clinical syndrome characterized by a progressive and selective inability to recognize and identify faces of familiar people. Here we report a patient (G.S.) with PP, mainly related to a prominent deficit in recognition of familiar faces, without a semantic (cross-modal) impairment. An in-depth evaluation showed that his deficit extended to other classes of objects, both living and non-living. A follow-up neuropsychological assessment did not reveal substantial changes after about 1 year. Structural MRI showed predominant right temporal lobe atrophy. Diffusion tensor imaging was performed to elucidate structural connectivity of the inferior longitudinal fasciculus (ILF) and the inferior fronto-occipital fasciculus (IFOF), the two major tracts that project through the core fusiform region to the anterior temporal and frontal cortices, respectively. Right ILF was markedly reduced in G.S., while left ILF and IFOFs were apparently preserved. These data are in favour of a crucial role of the neural circuit subserved by right ILF in the pathogenesis of PP.

KEYWORDS:

Diffusion tensor imaging; Inferior fronto-occipital fasciculus; Inferior longitudinal fasciculus; Progressive prosopagnosia

PMID:
23099263
DOI:
10.1016/j.cortex.2012.09.010
[Indexed for MEDLINE]
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