Format

Send to

Choose Destination
See comment in PubMed Commons below
Neurol Clin. 2012 Nov;30(4):1137-66. doi: 10.1016/j.ncl.2012.08.004.

Restless legs syndrome and periodic leg movements of sleep.

Author information

1
Program in Sleep, Department of Neurology, Emory University School of Medicine, 101 Woodruff Circle, WMRB-Office 6113, Atlanta, GA 30322, USA. drye@emory.edu

Abstract

Women are more commonly affected than men by restless legs syndrome, and prevalence is highest amongst those of northern European heritage. The motor manifestations include nonvolitional myoclonus (periodic leg movements). Disinhibition of spinal sensorimotor circuits may underlie these primary features and can be affected by peripheral as well as supraspinal networks. Insufficient mobilizable iron stores increase expressivity in some individuals. The sensorimotor features are relieved by dopamine, especially dopamine agonists, gabapentin and its derivatives, and opioids. A diagnosis relies on recognition of key primary and supportive features, and treatments are generally well tolerated, efficacious, and life-changing.

PMID:
23099132
DOI:
10.1016/j.ncl.2012.08.004
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center