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Trends Mol Med. 2012 Dec;18(12):732-41. doi: 10.1016/j.molmed.2012.09.009. Epub 2012 Oct 22.

Granzyme B in injury, inflammation, and repair.

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1
UBC James Hogg Research Centre, University of British Columbia, 166-1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada.

Abstract

Fragile skin and susceptibility to skin tearing are major problems among the elderly and can be complicated further by impaired wound healing. Non-healing wounds fail to progress through the normal stages of healing and enter a state of chronic inflammation featuring increased proteolytic activity. Increased expression of the serine protease granzyme B is observed during prolonged inflammation and is implicated in the pathogenesis of several chronic inflammatory diseases. Although its role in cytotoxic lymphocyte-mediated apoptosis is well established, granzyme B can also degrade extracellular matrix proteins and alter inflammation if present in the extracellular milieu. The present review focuses on the emerging evidence for the involvement of granzyme B in chronic inflammation, impaired wound healing, and age-related skin fragility.

PMID:
23099058
DOI:
10.1016/j.molmed.2012.09.009
[Indexed for MEDLINE]
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