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Phytochemistry. 2013 Jan;85:122-8. doi: 10.1016/j.phytochem.2012.09.008. Epub 2012 Oct 22.

Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities.

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1
School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, PR China. jianyd163@163.com

Abstract

Five sesquiterpenoids, 1α,8α-epidioxy-4α-hydroxy- 5αH-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4β-hydroxy-1α,5βH-7(11)-guaen-8,10-olide (2), 8α-hydroxy-1α, 4β,7βH-guai-10(15)-en- 5β,8β-endoxide(3), 7β,8α-dihydroxy-1α,4αH-guai-10(15)-en-5β,8β-endoxide(4) and 7-hydroxy-5(10),6,8-cadinatriene-4-one(5), together with seven known analogs were isolated from the rhizomes of Curcuma wenyujin. Their structures and relative configurations were determined on the basis of spectroscopic methods including 2D NMR techniques, and the structures of 1 and 2 were confirmed by single-crystal X-ray diffraction experiment. Compounds 1-10 and 12 showed significant in vitro antiviral activity against the influenza virus A with IC₅₀ values ranged from 6.80 to 39.97 μM, and SI values ranged from 6.35 to 37.25.

PMID:
23098899
DOI:
10.1016/j.phytochem.2012.09.008
[Indexed for MEDLINE]
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