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Int J Biochem Mol Biol. 2012;3(3):282-9. Epub 2012 Sep 25.

Hydroxyl radical generation theory: a possible explanation of unexplained actions of mammalian catalase.

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Department of Biochemistry, J.N. Medical College, Datta Meghe Institute of Medical Sciences (Deemed University) Wardha-442004, India.


Catalase is well known antioxidant enzyme which catalyses the dissociation of hydrogen peroxide directly into H(2)O and O(2). Mammalian catalase has been considered as 'a venerable enzyme with new mysteries'. Some aspects of its mechanism of action are mystifying and many of new findings are still unexplained. To fill up the gap we propose the 'Hydroxyl Radical Generation Theory (HRGT)' with possible mechanism. According to HRGT, mammalian catalase apart from its known catalytic reaction generates hydroxyl radicals (HRs). The HR generation mainly depends on concentration of specific substrate, hydrogen peroxide. The present theory is supported by previous experimental findings and has great deal of observational evidences. The proposed mechanism of generation of HRs answer several unexplained features of mammalian catalase, however, should be tested further.


Hydroxyl Radical Generation Theory (HRGT); Mammalian catalase; mechanism of action; role of NADPH


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