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ISRN Neurol. 2012;2012:427102. doi: 10.5402/2012/427102. Epub 2012 Oct 14.

Depression in multiple sclerosis: a review of assessment and treatment approaches in adult and pediatric populations.

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Department of Psychiatry, School of Medicine and University Hospital of Patras, University of Patras, Rio, 26504 Patras, Greece.


Multiple sclerosis is a chronic demyelinating disease affecting one million people worldwide, with a significant burden of psychiatric comorbidity. Depression is the commonest psychiatric manifestation but still remains largely underdiagnosed and undertreated. The present work reviews current knowledge on diagnosis, assessment, and somatic and psychotherapeutic treatment interventions for depression in adult and pediatric populations of patients with multiple sclerosis.

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