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Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):18S-26S. doi: 10.1097/PRS.0b013e31825efea6.

Cross-linking in biomaterials: a primer for clinicians.

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1
Division of Plastic Surgery, University of Massachusetts Medical School, 55 Lake Avenue North, S4-751, Worcester, MA 01655, USA. raymond.dunn@umassmemorial.org

Abstract

The purpose of this primer is to provide the clinical surgeon with a survey overview of the basic biochemistry of collagen and the methods and rationale of collagen cross-linking in the processing and preparation of bioprosthetics for surgical implantation. The author highlights the critical biologic factors, such as strength over time, integration, and rate, and type of remodeling, that are to an extent controllable by the cross-linking of collagen tissues so that clinicians may be better capable of understanding differences among the devices, which may be more applicable to their clinical indications.

PMID:
23096970
DOI:
10.1097/PRS.0b013e31825efea6
[Indexed for MEDLINE]
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