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Development. 2012 Dec 1;139(23):4416-27. doi: 10.1242/dev.082925. Epub 2012 Oct 24.

Cell cycle regulates cell type in the Arabidopsis sepal.

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  • 1Division of Biology, California Institute of Technology, Pasadena, CA 91125 USA. ahr75@cornell.edu

Abstract

The formation of cellular patterns during development requires the coordination of cell division with cell identity specification. This coordination is essential in patterning the highly elongated giant cells, which are interspersed between small cells, in the outer epidermis of the Arabidopsis thaliana sepal. Giant cells undergo endocycles, replicating their DNA without dividing, whereas small cells divide mitotically. We show that distinct enhancers are expressed in giant cells and small cells, indicating that these cell types have different identities as well as different sizes. We find that members of the epidermal specification pathway, DEFECTIVE KERNEL1 (DEK1), MERISTEM LAYER1 (ATML1), Arabidopsis CRINKLY4 (ACR4) and HOMEODOMAIN GLABROUS11 (HDG11), control the identity of giant cells. Giant cell identity is established upstream of cell cycle regulation. Conversely, endoreduplication represses small cell identity. These results show not only that cell type affects cell cycle regulation, but also that changes in the cell cycle can regulate cell type.

PMID:
23095885
DOI:
10.1242/dev.082925
[PubMed - indexed for MEDLINE]
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